Death Certificate: Two items can be taken from any given room, one for each character, if they're taken at the same time.Dead Cat: Only the character that takes it will be reduced to one heart container, but if either of the characters die, both characters are resurrected with one heart container.Bone Spurs: Bone projectiles spawn when either brother kills an enemy.Note that items that add pickups, such as A Quarter, will not add pickups again when copied. Birthright: The character who picks up the item gains copies of three of the other character's latest picked up passive items.If not listed here, and if applicable, an item will always apply all its effects on the character who picks/uses it only The items you can unlock by getting certain endings as Jacob and Esau are very good for future runs (Ex: Birthright) so unlocking those items could be a priority as soon as Jacob and Esau are unlocked.When entering the Mirror World, only either Jacob or Esau need to be The Lost while the other can enter it with full health. If either Jacob or Esau have familiars and the other has Extension Cord, electricity will also arc between both characters, and between familiars and the character that didn't pick them up.If the two characters each own a copy of the same resurrection item, the game prioritizes removing Jacob's item. Resurrection items activate in a set order, regardless of who owns which item.Meaning at base stats, they effectively start with 0 Luck for this purpose. For the purposes of Room Clear Awards, the room drop rate depends on the total luck the 2 characters have.Despite flying items like Fate only affecting the one who picked it up, it's still very useful if you only focus on the brother that is NOT using it, as the flying one will never get caught on obstacles.The extra required hearts will not be removed from the other character. Contrarily, if one has 2+ red heart containers and half a soul heart he can pay for a 3 soul heart deal with only half a soul heart, or if one has 1 red heart container, he can pay for a 2 red heart deal with only 1 red heart.Jacob takes a deal that leaves him with no red hearts, the deals may change prices to accommodate for the lack of red hearts, so if the deal requires all soul hearts and Esau only has red heart containers, he will not be able to take the deal.Devil deals are variable for Jacob and Esau, as the prices may dynamically change based on either of them, which can make it so the other may not be able to take the deal, but can also allow the deals to be underpaid.Mom's Shovel will only form if both pieces are held by the same character. This does not work with Broken Shovel/ Broken Shovel.Key Piece 1/ Key Piece 2 and Knife Piece 1/ Knife Piece 2 will combine regardless of whether they are split up or carried by one character. Dice rooms with 1 pip will only reroll the items of the character that triggered the room. Dice rooms with 6 pips will reroll held items of both characters regardless of whoever triggered the room.All Esau's held cards/pills/trinkets are dropped on the ground. Transforming into a new character with items like Clicker or Judas' Shadow will grant both of Jacob and Esau's collected items to the new character.For example, if a Library is encountered, and there are 3 book active items, once Jacob picks up all 3 books, Esau can't get the Bookworm transformation unless the pedestal is rerolled through The D6 or other similar pedestal rolling items. This is most notable with books for the Bookworm transformation: each character needs 3 different books. Active items involved in Transformations count only for the character who touched the item first.
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